Shaw Lab

Publications

 

Select Publications

Vosbigian K.A., Wright S.J., Rosche K.L., Fisk E.A., Ramirez-Zepp E., Shelden E.A., Shaw D.K. “ATF6 enables pathogen infection in ticks by inducing stomatin and altering cholesterol dynamics”. BioRxiv [Preprint]. 2025 Jan 8. 2025.01.08.632023. doi: 10.1101/2025.01.08.632023

Park, J.M., Genera, B.M., Fahy, D., Swallow, K.T., Nelson, C.M., Oliver, J.D., Shaw, D.K., Munderloh, U.G., Brayton, K.A. “An Anaplasma phagocytophilum T4SS effector, AteA, is essential for tick infection”. mBio. 2023 September 25. DOI: 10.1128/mbio.01711-23.

Rosche, K.L., Hurtado, J., Fisk, E.A., Vosbigian, K.A., Warren, A.L., Sidak-Loftis, L.C., Wright, S.J., Ramirez-Zepp, E., Park, J.M., Shaw, D.K. “PERK-mediated antioxidant response is key for pathogen persistence in ticks”. mSphere. 2023 September 21. DOI: 10.1128/msphere.00321-23.

O'Neal, A.J., Singh, N., Rolandelli, A., Laukaitis, H., Wang, X., Shaw, D.K., Young, B.D., Narasimhan, S., Dutta, S., Snyder, G.A., Samaddar, S., Marnin, L., Butler, L.R., Tays Mendes, M., Cabrera Paz, F.E., Valencia, L.M., Sundberg, E.J., Fikrig, E., Pal, U., Weber, D.J., Pedra, J.H.F. “Croquemort elicits activation of the immune deficiency pathway in ticks”. Proc Natl Acad Sci U S A. 2023 May 16. DOI: 10.1073/pnas.2208673120.

Sidak-Loftis, L.C., Rosche, K.L., Pence, N., Ujczo, J.K., Hurtado, J., Fisk, E.A., Goodman, A.G., Noh, S.M., Peters, J.W., Shaw, D.K. “The Unfolded-Protein Response Triggers the Arthropod Immune Deficiency Pathway”. mBio. 2022 July 18. DOI: 10.1128/mbio.00703-22

Park, J.M., Oliva Chávez, A.S., Shaw, D.K. “Ticks: More than just a pathogen delivery service”. Front. Cell. Infect. Microbiol. 2021 Sept 1. DOI: 10.3389/fcimb.2021.739419

Oliva Chávez, A.S., Wang, X., Marnin, L., Archer, N., Hammond, H.L., McClure Carroll, E.E., Shaw, D.K., Tully, B.G., Buskirk, A.D., Ford, S.L., Butler, R., Shahi, P., Morozova, K., Clement, C.C., Lawres, L., O’Neal, A.J., Mamoun, C.B., Mason, K.L., Hobbs, B.E., Scoles, G.A., Barry, E.M., Sonenshine, D.E., Pal, U., Valenzuela, J.G., Sztein, M.B., Pasetti, M.F., Levin, M.L., Kotsyfakis, M., Jay, S.M., Huntley, J.F., Miller, L., Santambrogio, L., Pedra, J.H.F. “Tick Extracellular Vesicles Enable Arthropod Feeding and Promote Distinct Outcomes of Bacterial Infection”. Nat. Commun. 2021 June 17;12(1):3696. doi: 10.1038/s41467-021-23900-8.

Rosche, K.L., Sidak-Loftis, L.C., Hurtado, J., Fisk, E.A., Shaw, D.K. “Arthropods Under Pressure: Stress Responses and Immunity at the Pathogen-Vector Interface”. Front. Immunol. 2021 Feb 15. doi: 10.3389/fimmu.2020.629777

McClure Carroll, E.E., Wang, X., Shaw, D.K., O’Neal, A.J., Oliva Chávez, A.S., Brown, L.J., Boradia, V.M., Hammond, H.L, Pedra, J.H.F. “p47 Licenses Activation of the Immune Deficiency Pathway in the Tick Ixodes scapularis”. PNAS. January 2, 2019. 116 (1) 205-210 doi.org/10.1073/pnas.1808905116

Shaw, D.K., Tate, A.T., Schneider, D.S., Levashina, E.A., Kagan, J.C., Pal, U., Fikrig, E., Pedra, J.H.F. “Vector Immunity and Evolutionary Ecology: The Harmonious Dissonance”. Trends Immunol. 2018 Oct 6. pii: S1471-4906(18)30168-6. doi: 10.1016/j.it.2018.09.003

McClure, E.E. ,Oliva Chávez, A.S., Shaw, D.K., Carlyon, J.A., Ganta, R.R., Noh, S.M., Wood, D.O., Bavoil, P.M., Brayton, K.A., Martinez, J.J., McBride, J.W., Valdivia, R.H., Munderloh, U.G., Pedra, J.H.F. “Genetic Manipulation of Obligate Intracellular Bacteria: Advances and Challenges”. Nat Rev Microbiol. 2017. (9) 544-558. doi: 10.1038/nrmicro.2017.59.

Shaw, D.K., Wang, X., Brown, L.J., Chávez, A.S., Reif, K.E., Smith, A.A., Scott, A.J., McClure, E.E., Boradia, V.M., Hammond, H.L., Sundberg, E.J., Snyder, G.A., Liu, L., DePonte, K., Villar, M., Ueti, M.W., de la Fuente, J., Ernst, R.K., Pal, U., Fikrig, E., Pedra, J.H.F. “Infection-Derived Lipids Elicit a Novel Immune Deficiency Circuitry in Arthropods”. Nat. Commun. 2017. (8) 14401. doi: 10.1038/ncomms14401.

Oliva Chávez, A.S., Shaw, D.K., Munderloh, U.G., Pedra, J.H.F. “Tick Humoral Responses: Marching to the Beat of a Different Drummer”. Front. Microbiol. 2017. (8):223. doi: 10.3389/fmicb.2017.00223.

Wang X., Shaw D.K., Hammond H.L., Sutterwala F.S., Rayamajhi M., Shirey K.A., Perkins D.J., Bonventre J.V., Velayutham T.S., Evans S.M., Rodino K.G., VieBrock L., Scanlon K.M., Carbonetti N.H., Carlyon J.A., Miao E.A., McBride J.W., Kotsyfakis M., Pedra J.H.F. “The Prostaglandin E2-EP3 Receptor Axis Regulates Anaplasma phagocytophilum-Mediated NLRC4 Inflammasome Activation”. PLoS Pathog. 2016 Aug 2;12(8):e1005803. doi: 10.1371/journal.ppat.1005803. 

Wang X., Shaw D.K., Sakhon O.S., Snyder G.A., Sundberg E.J., Santambrogio L., Sutterwala F.S., Dumler J.S., Shirey K.A., Perkins D.J., Richard K., Chagas A.C., Calvo E., Kopecký J., Kotsyfakis M., Pedra J.H.F. “The Tick Protein Sialostatin L2 Binds to Annexin A2 and Inhibits NLRC4-Mediated Inflammasome Activation”. Infect Immun. 2016 May 24;84(6):1796-1805. doi: 10.1128/IAI.01526-15.

Shaw D.K., Kotsyfakis M., Pedra J.H.F. "For Whom the Bell Tolls (and Nods): Spit-acular Saliva". Curr Trop Med Rep. 2016 Jun;3(2):40-50. Epub 2016 Apr 5.

Shaw, D.K., Hyde, J.A. and Skare, J.T. “The Borrelia burgdorferi BB0646 Protein is Responsible for the Lipase and Hemolytic Activity Associated with the Etiological Agent of Lyme Disease”. Mol Microbiol. 2012 Jan;83(2):319-34. doi: 10.1111/j.1365-2958.2011.07932.x. 

 

complete list of publications linked here