September
This month Chelsea Osbron and Brianna Steiert join the lab as postdoctoral fellows!
Chelsea graduated this last summer with her PhD from the Washington State University, College of Veterinary Medicine. Her dissertation work in Dr. Alan Goodman’s lab centered on cell death pathway manipulation by Coxiella burnetii.
Brianna graduated with her PhD from the University of Iowa, Carver College of Medicine this last summer. Her PhD work in Dr. Mary Weber’s lab focused on host-pathogen interactions with Chlamydia trachomatis.
Welcome Brianna and Chelsea!!
July 2024
This month, we had several lab members travel to Williamsburg, VA for the 2024 American Society for Rickettsiology meeting!
Kaylee Vosbigian and Cameron Coyle both presented research posters
Dana gave an invited oral presentation
We got to catch up with in-coming lab members, Dr. Brianna Steiert (University of Iowa) and Dr. Chelsea Osbron (Washington State University), who will be joining the lab on September 1st! (more to come)
Cameron was the recipient of an American Society for Rickettsiology travel award - congrats, Cam!!
Kaylee and Cameron were both the recipients of a department Veterinary Microbiology and Pathology travel awards - congrats Kaylee and Cam!!
We saw Lindsay Sidak-Loftis off as she heads for her next position at the NIH with Dr. Tais Saito - good luck, Lindsay!!
Cameron was highlighted in the Washington State University, College of Veterinary Medicine graduate student spotlight series - check out what she has to say here!
We had a collaborative project with Joao Pedra’s lab published in Nature Microbiology this month, that can be found here!: PMID 38997520
June 2024
This month, Elis Fisk successfully completed the the ACVP Phase 1 Examination - BIG congrats, Elis!!
Spring 2024
It has been a busy Spring semester for the Shaw lab with awards, travels, prelims, and temporary send-offs. Here’s what we have been up to!
Kaylee Vosbigian and Cameron Coyle both successfully defended their proposals, passed prelims and advanced to PhD candidacy on May 3rd and May 8th (respectively) - big congrats to Kaylee and Cameron!!
Elis Fisk was a recipient of the 2024 BIOONE AMBASSADOR AWARD – Draw and Learn: A Bighorn Sheep Mystery; nominated by The Wildlife Disease Association for his research published in the Journal of Wildlife Diseases (Abortion and Neonatal Mortality Due to Toxoplasma gondii in Bighorn Sheep (Ovis canadensis), 59: 37-48. 2023. This award recognizes early-career researchers in the biological, ecological, and environmental sciences who demonstrate creative approaches to science communication. Check out Elis’ video here!: https://bioonepublishing.org/our-work/2024-ambassadors/
Cameron Coyle presented a research poster at the 35th annual NIH Protein Biotechnology Symposium on April 4th.
Cameron Coyle was awarded a competitive CVM Scholarship, the Ron and Sheila Pera Award - congrats, Cam!!
Dana traveled to the South Texas Center for Emerging Infectious Diseases at the University of Texas, San Antonio on April 5th for an invited seminar titled “Tick immunity vs. pathogen persistence: the molecular tug of war that shapes vector competence”. She had an excellent time visiting with faculty, students, and host Janakiram Seshu!
The lab was awarded a College of Veterinary Medicine seed grant to continue our studies on vector competence of ticks! Grateful to be part of this supportive research environment- Go Cougs! 🐾
We published a couple of collaborative projects in Infection and Immunity (PMID: 38363133) with Alan Goodman’s group and Parasites and Vectors (PMID: 38336752) with Joao Pedra’s group.
We saw Cameron Coyle off for her summer research internship at Zoetis - she will be missed! But will be back for the Fall semester - have fun, Cam!
Dana was awarded tenure!!! So very grateful for the hard work and talent of current and former lab members, for guidance from mentors, for the support of wonderful colleagues both at Washington State University and in the larger scientific community. I feel very fortunate to work day-in and day-out with such a wonderful group. Thank you!!
Closing out the Spring, the Northern Lights were visible in Pullman and put on a spectacular show 🤩
December 2023
2023 closed out with some good things for the Shaw lab!
Dr. Lindsay Sidak-Loftis graduated with her PhD in Biomedical Sciences
We were awarded an NIH R61 grant along with Drs. Kelly Brayton and Jason Park for developing genetic tools in rickettsial pathogens - excited to start expanding the genetic toolbox for these bugs!
November 2023
This was an exciting month with Lindsay Sidak-Loftis successfully defending her dissertation! (titled “Unraveling arthropod immunity: Investigating the unfolded protein response as an initiator of the immune deficiency pathway in Ixodes scapularis ticks”)! Lindsay is the first PhD student out of the Shaw lab and we are super proud of all of her accomplishments!! Congrats, Lindsay!
We also had some conference travel here in the PNW!
Kaylee Vosbigian presented a poster at the CVM Research Symposium on titled “Pathogen persistence in ticks is supported by ATF6 and Nrf2 gene regulation”
Kaylee Vosbigian and Sarah Wright traveled to Portland, OR on for the American Society of Microbiology Northwestern Branch Meeting to present posters on their research.
October 2023
This has been a busy Fall semester with lots of conference presentations and awards!
Elis Fisk traveled to Chicago, IL for the annual ACVP meeting to present his poster titled “Forbidden snack: C57BL/6 mice as a model for acquired resistance to Ixodes scapularis”
Elis was also the recipient of the 2023 Davis-Thompson Foundation Pathology Trainee Scholarship Award, which goes to trainees who have demonstrated superior scholarship, exceptional diagnostic skills, mentorship, leadership, in addition to talent and enthusiasm for teaching - congrats, Elis!
Kaylee Vosbigian was the recipient of the 2023 Excellence in Research Award, which celebrates students with exceptional contributions to the scientific community and who have prioritized mentorship and collaboration within VMP - congrats, Kaylee!
Dana traveled to the University of Nebraska Medical Center on Oct. 10-11 for an invited research talk titled “Tick immunity vs. pathogen persistence: the molecular tug of war that shapes vector competence” and was also the recipient of WSU’s 2023 Pacesetter Award!
September 2023
The Fall semester has started and we have new faces in the lab! Alyssa Maine, a first-year IID PhD student, and Cierra Grove, an undergraduate Genetics and Cell Biology MARC Scholar, are joining us for rotations - welcome Alyssa and Cierra!
Dana traveled to Iowa City, IA to visit the University of Iowa College of Medicine and old friend from grad school, Mary Weber, PhD. She presented a seminar titled “From stress to defense: unraveling the UPR’s role in tick immunity and vector competency” and had an excellent time visiting with Mary and the University of Iowa folks!
The lab’s most recent story is now available on mSphere and was chosen as the Editor’s pick!
In this story, we address what sorts of elements allow tick-borne pathogens to survive in ticks. We know that tick immune responses produce molecules that restrict transmissible pathogens like Borrelia and Anaplasma. So how are these microbes persisting in ticks?
We found that the PERK-eIF2α-ATF4 pathway is induced in infected Ixodes ticks, which leads to an Nrf2-driven antioxidant response. Activity of this pathway supports microbial persistence by detoxifying reactive oxygen and nitrogen species.
Overall, these results highlight the mechanistic push and pull between arthropod immunity and pathogen persistence in ticks!
July 2023
July was a busy month for the Shaw lab- more conference travel and presentations and Elis passed his prelims! PLUS, our newest manuscript was accepted to mSphere and will be out soon (for now, is available on BioRxiv)!
The American Society for Rickettsiology was held in Snowbird Utah July 8-11, and was well attended by WSU.
Kaylee gave an invited oral presentation titled “Stressed for success: How the Unfolded Protein Response in Ixodes scapularis intertwines with pathogen survival”.
Lindsay presented a poster titled “Unfolding vector immunity and advancing research tools for Ixodes scapularis”.
Dana presented a poster titled “PERK-mediated antioxidant response is key for pathogen persistence in ticks”.
June 2023
Lots of conference travel and presentations this month for the Shaw lab!
Dana traveled to The Endoplasmic Reticulum (ER) Conference: Structure, Function and Disease Research Conference (FASEB) in Melbourne, FL on June 11-15 for an invited presentation titled “How stress responses and immunity intertwine to regulate vector competence of ticks”.
Lindsay and Dana traveled to The American Society for Microbiology 2023 meeting in Houston, TX June 15-18.
Lindsay gave an invited presentation titled “Shaping the understanding of the Unfolded Protein Response and Vector Competency in Ixodes scapularis”.
Dana was invited to talk about “How stress responses and immunity intertwine to regulate vector competence of ticks”. However, laryngitis prevented her from presenting, so Lindsay presented in her place and did a fantastic job!
Lindsay traveled to Roscoff (Bretagne), France for the Insect Models for Infection Biology meeting June 26-30 for a poster presentation and a Flash Talk titled “Unfolding vector immunity and advancing research tools for Ixodes scapularis”.
May 2023
BIG congrats to Sarah Wright for graduating from WSU this month! Lucky for us, Sarah will be staying on a Research Intern in the Shaw Lab and we are very happy to have her.
On May 17, Dana gave an invited talk titled “Tick-pathogen interactions: stress responses intersect with arthropod immunity to regulate vector competence” at the NIH NIAID workshop, Understanding Immune Evasion in Tickborne Diseases.
April 2023
Elis Fisk and Kaylee Vosbigian presented posters on April 7 at Institute for Health in the Human Ecosystem Annual Research Symposium in Moscow, ID. Elis’ poster was titled “Acquired Resistance to larval Ixodes scapularis in Mus musculus" and Kaylee presented her work on “Dissecting the Unfolded Protein Response gene regulatory network in Ixodes scapularis during infection”.
Kaylee also presented a poster on April 13 titled “Stressed for success: How the Unfolded Protein Response in Ixodes scapularis intertwines with pathogen survival” at WSU’s Biotech Research Symposium.
Lindsay Sidak-Loftis and Kaylee Vosbigian were the recipients of two of the 2023 WSU College of Veterinary Medicine awards. Lindsay was awarded the Dr. John R. Gorham Fellowship and Kaylee recieved the Ronald J. and Sheila S. Pera Endowed Scholarship. Congrats to both Lindsay and Kaylee - these were well-deserved!!
Elis and Kaylee presenting at the Institute for Health in the Human Ecosystem Annual Research Symposium in Moscow, ID
February 2023
Elis Fisk and Dana traveled to Breckenridge, CO for the Keystone Symposia Vector Biology: Emerging Concepts and Novel Technologies on Feb. 13-16 where Elis presented his research poster titled “Acquired resistance to larval Ixodes scapularis in Mus musculus”.
Big welcome to our two newest lab members!
Cameron Coyle is a PhD student in the IID program
Sarah Wright is a senior Microbiology major at WSU
November 2022
Lindsay Sidak-Loftis and Kaylee (Andrews) Vosbigian traveled to Spokane, WA on Nov. 4-5 and presented research posters at American Society for Microbiology Northwest Branch Meeting. Lindsay’s poster was titled “Shaping the understanding of the Unfolded Protein Response and vector competency in Ixodes scapularis” and Kaylee’s poster was titled “Dissecting the Unfolded Protein Response gene regulatory network in Ixodes scapularis during infection”.
Lindsay Sidak-Loftis and Kaylee (Andrews) Vosbigian presented their research posters at the WSU CVM Research Symposium on Nov. 10.
Lindsay Sidak-Loftis won best graduate student poster presentation at both the American Society for Microbiology Northwest Branch Meeting and the WSU CVM Research Symposium.
Dana traveled to Milwaukee, WI on Nov. 7-9 for an invited seminar at The Medical College of Wisconsin and had an excellent time visiting with the faculty, students, and hosts Drs. Jenifer Coburn and Michelle Riehle. The title of her talk was “Tick talk: how stress responses intersect with immunity to regulate vector competence”.
Dana was awarded the Dean’s Outstanding Junior Faculty Research Award at the WSU CVM Research Symposium.
October 2022
Big congrats to Lindsay Sidak-Loftis was awarded the Kraft Graduate Student Scholarship in October!
Dana had an awesome time visiting Dr. Laura Levine and our on-campus neighbors in the Department of Entomology on Oct. 10 to give a seminar titled “Stress responses influence vector competency of ticks by eliciting a novel mode of IMD pathway activation”.
Dana was named the next G. Caroline Engle Distinguished Professor. G. Caroline Engle graduated from WSU with her DVM degree in 1967. During her veterinary program at WSU she worked with Professor G. Roger Spencer. Based upon her very positive relationships with the infectious diseases program personnel over many years at the WSU CVM, Caroline established the Caroline Engle Distinguished Professorship in Research on Infectious Diseases. She provided guidance in that she wanted her gifts to promote the infectious diseases research programs of VMP.
Charles Ugwu, 1st year PhD student in School of Molecular Biosciences, is rotating with us this Fall for the next 8 weeks - welcome!
September 2022
The Fall semester has started and we have some updates!
Big congrats to Elis Fisk, who was awarded an NIH T32 post-doctoral training scholarship in Infectious Diseases and Microbial Immunology!
Nice write up about Elis can be found here: Infectious disease and immunology fellow to continue research into tick disease
We have also had several new people in the lab this month- Welcome!:
Kaylee (Andrews) Vosbigian, a PhD student in the IID program
Lizzy Ramirez-Zepp, an ESTEEMED MIRA undergraduate scholar
Cameron Coyle, a rotation PhD student in the IID program
WSU Insider wrote a nice feature highlight about our group and our recent mBio publication:
July 2022
July came with some exciting news:
Our story “The Unfolded-Protein Response Triggers the Arthropod Immune Deficiency Pathway” is now published in mBio and available to read online!
At the start of the month, we received news that our R01 application was funded through NIAID! This project is entitled “Tick-Pathogen Interactions: Exploring the Intersection between Stress Responses and Immunity” and builds on the findings reported in our mBio story. We are so excited to have the opportunity to continue investigating how stress responses impact tick immunity and vector competence!
June 2022
June was a busy month for the Shaw Lab!
Dana traveled to South Bend, IN for the Arthropod Genomics Symposium held at Notre Dame University from June 9-11. She gave a presentation titled “Stress responses elicit a noncanonical mode of IMD pathway activation in ticks” and got wonderful feedback from colleagues!
Dana and Lindsay both traveled to Greenville, SC June 24-28 for the American Society in Rickettsiology meeting. Dana gave a talk titled “Arthropod vectors: More than mobile syringes” and Lindsay did a wonderful job presenting her poster titled “Shaping the understanding of the Unfolded Protein Response and Vector Competency in Ixodes scapularis”. While there, Lindsay was awarded an ASR travel award - congrats Lindsay!
Lastly, the lab’s very FIRST research paper was accepted for publication in mBio! This is also Lindsay’s first, first-author publication from our lab - congrats Lindsay!! Stay tuned for the mBio link…
It was great seeing our colleagues again in-person for the first time in several years. Looking forward to more hang outs with our science peeps!
May 2022
We have many things to celebrate this month in the Shaw lab!
Lindsay Sidak-Loftis was selected as a 2022-2023 Poncin Fellow! This award is intended to aid worthy and ambitious young people who are engaged in biomedical research at any recognized institution of learning within the State of Washington. This is a well-deserved recognition of Lindsay’s research accomplishments and potential. Congratulations, Lindsay!
Ashley Warren is joining us as the newest Shaw lab member! Ashley comes to us with a DVM from Cornell University and is now an IID graduate student in the combined Residency/PhD program. Welcome, Ashley!
Ashley is also the winner of the Design a Better Pathogen competition this year! Ashley’s pathogen, Balamuthia millennii, is the causative agent of Millennial Encephalic Amoebiasis and is transmitted through contaminated avocados. A secreted effector molecule, KaREN, causes behavioral changes resulting in symptoms such as an affinity for brunch and avocado toast.
The Design a Better Pathogen competition is the final project of the IID program course, Mechanisms of Disease. This is an exercise where students will dream up a satirical pathogen and give a 10 min. presentation to the department that introduces the microbe and describes mechanisms that cause the associated disease. At the end presenters then field questions from the audience. Congrats to Ashley on a well-deserved win!